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The concept of leaky gut refers to compromised intestinal barrier function allowing inappropriate passage of substances into the bloodstream

741 PyrC is a dihydroorotase (DHOase) that catalyzes the reversible interconversion of carbamoyl aspartate (CAA) and dihydroorotate (DHO) and functions in the third step of de novo pyrimidine biosynthesis, just downstream of the committed step catalyzed by another Zn-metalloenzyme, aspartate transcarbamoylase

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The BMJ clinical review notes that route selection should be based on the cause of deficiency rather than preference alone